Access minimserver from outside network4/24/2023 ![]() ![]() These studies were performed in accordance with the Helsinki declaration. In both studies, all participants provided written informed consent. Ethical approval for the LBC1921 and LBC1936 studies was obtained from the Multi-Centre Research Ethics Committee for Scotland (MREC/01/0/56) and the Lothian Research Ethics committee (LREC/83 LREC/9). GS has also been granted Research Tissue Bank status by the East of Scotland Research Ethics Service (REC Reference Number: 20-ES-0021), providing generic ethical approval for a wide range of uses within medical research. The details of the IRB/oversight body that provided approval or exemption for the research described are given below:Īll components of GS received ethical approval from the NHS Tayside Committee on Medical Research Ethics (REC Reference Number: 05/S1401/89). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. REM is supported by Alzheimer's Society major project grant AS-PG-19b-010. CM, TG, and BR are supported by the United Kingdom Research and Innovation (grant EP/S02431X/1), UKRI Centre for Doctoral Training in Biomedical AI at the University of Edinburgh, School of Informatics. Methylation typing was supported by the Centre for Cognitive Ageing and Cognitive Epidemiology (Pilot Fund award), Age UK, The Wellcome Trust Institutional Strategic Support Fund, The University of Edinburgh, and The University of Queensland. The LBC1921 was supported by the Biotechnology and Biological Sciences Research Council, the Chief Scientist Office of the Scottish Government, the Royal Society and the Medical Research Council. The LBC1936 is supported by the Biotechnology and Biological Sciences Research Council, and the Economic and Social Research Council, Age UK (Disconnected Mind project), the Milton Damerel Trust, and the University of Edinburgh. The authors thank all LBC study participants and research team members who have contributed, and continue to contribute, to the ongoing LBC study. Genotyping of the GS samples was carried out by the Genetics Core Laboratory at the Edinburgh Clinical Research Facility, University of Edinburgh, Scotland and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award "STratifying Resilience and Depression Longitudinally" (STRADL) Reference 104036/Z/14/Z). Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates and the Scottish Funding Council and is currently supported by the Wellcome Trust. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. This research was funded in whole, or in part, by the Wellcome Trust (104036/Z/14/Z and 216767/Z/19/Z). LM has received payment from Illumina for presentations and consultancy. RFH is a scientific advisor to Optima Partners. REM is a scientific advisor to the Epigenetic Clock Development Foundation and Optima Partners. These methods are especially important for cases where when raw data and joint normalisation of cohorts is not possible or is computationally expensive. Conclusions Using normalisation methods that give similar EpiScores whether cohorts are analysed separately or together will minimise technical variation when projecting new data onto a reference panel.
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